Examining the Link Between Breast Cancer and Genetics

Do inherited genetic mutations affect your likelihood of developing breast cancer? Local experts weigh in on the DNA-cancer link.



Published:

The reality of breast cancer hit Tracy Elliman early. She was 10 when she lost her grandmother to the disease. While her grandmother was dying, her mother was diagnosed with Stage 3 breast cancer. Seven years later, her mother developed a new cancer in the other breast.

“We never thought of the connection,” says Elliman, 41, of Kennett Square, Pa. “We just thought it was a terrible coincidence.”

But the discovery of the breast cancer genes raised their suspicions. They wanted to know if the mutations resided in their DNA. It was 2004 and by that time, Elliman was married and the mother of two young children. The testing confirmed their fears: both were carriers of the BRCA 1 mutation.

Women without a BRCA mutation or a strong family history of breast cancer have a 13 percent lifetime risk of developing breast cancer compared to a 60 percent risk for women with the harmful genes. The mutations also increase the risk for developing ovarian cancer.

Elliman enrolled in two clinical trials designed to screen her for both cancers. But living with the fear of developing breast cancer was taking its toll and when funding for one of the programs was cut, she opted for prophylactic surgery. Her ovaries and tubes were removed in 2008. The following year she underwent a bilateral mastectomy and reconstruction.

The surgery reduced her risk of developing a breast cancer by about 90 percent.

Elliman found the decision empowering. “I had done my homework and felt I was in the right place,” she says. “I knew I was doing the right thing.”

Fewer than 10 percent of all breast cancers are thought to be due to this inherited genetic mutation. Researchers estimate that one in every 300 to 500 people carries a BRCA mutation.

“It’s a fairly small group of extremely high-risk people who are carrying the mutation,” says Dr. Diana Dickson-Witmer, surgeon and medical director of the Breast Center at the Helen F. Graham Center at Christiana Care Health System.

A BRCA genetic mutation is more likely to run in a family if: many women in the family have had breast and/or ovarian cancers, particularly before age 50; there are instances of bilateral breast cancers; a male relative has had breast cancer or early onset prostate cancer; a history of gastrointestinal cancers; or the family is of Eastern European Jewish descent.

But even if you don’t fall into any of these categories, you’re not out of the woods. Women without a strong family history of breast and other cancers can still be at a high risk for developing breast cancer.

“When you have a striking family history and you test negative (for either BRCA mutation), then it most likely means a different gene that we haven’t discovered yet or we’re unable to test for yet,” says Zohra Ali Khan-Catts, director of Cancer Genetic Counseling at Christiana Care Health System.

Dickson-Witmer stresses the need for women to educate themselves about their risk for breast cancer when considering surgical options to prevent the disease.

“There’s no question if your risk of developing a breast cancer is upwards of 60 percent, that if you reduce that by 90 percent, then it’s worth sacrificing your breasts,” she says. “But in groups of women who are at moderate risk, it is not worth the risk of surgical trauma or sometimes years of chest-wall discomfort that can be the true price of having both breasts removed.”


For more about the Delaware Breast Cancer coalition, click here.

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February 2018

A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
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Telephone: 302-654-8638
Website »

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This community-curated exhibition brings together three painters—Alan Soffer, Brian Dickerson, and Moe Brooker—who are attuned to harmonies and contrasts in abstract forms. Each artist...

Cost: Free with Museum admission

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »


Website »

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The Philly Home + Garden Show will return to the Greater Philadelphia Expo Center at Oaks February 16-18. The show will feature highly-interactive exhibits including a full scale model smart home,...

Cost: 10

Where:
Greater Philadelphia Expo Center
100 Station Ave
Oaks, PA  19456
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Sponsor: MarketPlace Events
Contact Name:

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By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
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The Rehoboth Beach Film Society in partnership with The Southern Delaware Alliance for Racial Justice are proud to present the inaugural Rehoboth Beach African-American Film Festival. The mission...

Cost: $10

Where:
Cinema Art Theater
17701 Dartmouth Drive, #2
Lewes, DE
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Sponsor: Rehoboth Beach Film Society
Telephone: 302-645-9095
Contact Name: Jeri Kaplan
Website »

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"Choir Boy" presents a complex look at race and sexuality. Shows are at 8pm on February 16 and 17; there is a 2pm matinee on Sunday February 18. Buy tickets online at www.WilmingtonDramaLeague.org.

Cost: $10-$15

Where:
Wilmington Drama League
10 West Lea Blvd.
Wilmington, DE  19802
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Sponsor: Wilmington Drama League
Telephone: 302-764-1172
Website »

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"What the water said…Flowers, Places, & Faces," an exhibition of watercolor paintings by Hugh Phibbs, will be on view in the Mezzanine Gallery from February 2-23, 2018. A free...

Cost: Free

Where:
Mezzanine Gallery
Carvel State Office Building, 2nd Floor
820 N. French St.
Wilmington, DE  19801
View map »


Sponsor: Delaware Division of the Arts
Telephone: 302-577-8278
Contact Name: Roxanne Stanulis
Website »

More information

A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
View map »


Telephone: 302-654-8638
Website »

More information

By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
View map »

More information

Tickets are $15 adults; $10 UD faculty/staff/alumni & seniors; $5 students. Tickets are available at the door. Cash or check only.

Cost: $15 adults; $10 UD faculty/staff/alumni & seniors; $5 students

Where:
Gore Recital Hall
110 Orchard Rd
Newark, DE  19716
View map »


Sponsor: University of Delaware Department of Music
Telephone: 130-283-12578
Contact Name: Megan Everhart
Website »

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"What the water said…Flowers, Places, & Faces," an exhibition of watercolor paintings by Hugh Phibbs, will be on view in the Mezzanine Gallery from February 2-23, 2018. A free...

Cost: Free

Where:
Mezzanine Gallery
Carvel State Office Building, 2nd Floor
820 N. French St.
Wilmington, DE  19801
View map »


Sponsor: Delaware Division of the Arts
Telephone: 302-577-8278
Contact Name: Roxanne Stanulis
Website »

More information

A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
View map »


Telephone: 302-654-8638
Website »

More information

Nanticoke Memorial Hospital will host a four-session diabetes educational program, The Diabetes Connection, on February 6, 13, 20 and 27 from 9:30 am to 11:30 am. Pre-registration is required. As...

Cost: Call for cost.

Where:
Nanticoke Memorial Hospital
801 Middleford Road
Seaford, DE  19973
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Telephone: 302-629-6611 x2288
Contact Name: Nanticoke's Diabetes Education Department
Website »

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By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
View map »

More information

Show More...
Show Less...

"What the water said…Flowers, Places, & Faces," an exhibition of watercolor paintings by Hugh Phibbs, will be on view in the Mezzanine Gallery from February 2-23, 2018. A free...

Cost: Free

Where:
Mezzanine Gallery
Carvel State Office Building, 2nd Floor
820 N. French St.
Wilmington, DE  19801
View map »


Sponsor: Delaware Division of the Arts
Telephone: 302-577-8278
Contact Name: Roxanne Stanulis
Website »

More information

A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
View map »


Telephone: 302-654-8638
Website »

More information

This community-curated exhibition brings together three painters—Alan Soffer, Brian Dickerson, and Moe Brooker—who are attuned to harmonies and contrasts in abstract forms. Each artist...

Cost: Free with Museum admission

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »


Website »

More information

FREE COMMUNITY EVENT: MID-WEEK WORD REFRESHER Come join us at the Mid-Week Word Refresher every Wednesday at Faith Victory Christian Center from 11:00am - 12:00pm. Refreshments will be...

Cost: FREE

Where:
Faith Victory Christian Center
301 Commonwealth Avenue
Claymont, DE  19703
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Sponsor: Faith Victory Christian Center
Telephone: 302.354.6726
Contact Name: Alvin Walker
Website »

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By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
View map »

More information

Join DCH, New Castle Conservation District staff, and Delaware Cooperative Extension to grow and learn together through an entire season! Classes are designed for a beginner, but seasoned gardeners...

Cost: $20 members; $30 non-members

Where:
Delaware Center for Horticulture
1810 N. Dupont Street
Wilmington, DE  19806
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Sponsor: Delaware Center for Horticulture
Telephone: (302) 658-6262
Contact Name: Ruth Arias
Website »

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Clearing the mind and learning to think not thinking is Zen awareness. Taking the appropriate action in this moment is Zen. Once you know this in your body, walking, standing, sitting down,...

Cost: Free

Where:
Unitarian Universalist Fellowship of Newark
420 Willa Road
Newark, DE  19711
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Sponsor: UUFN
Telephone: 302.368.2984
Contact Name: Richard Field
Website »

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"What the water said…Flowers, Places, & Faces," an exhibition of watercolor paintings by Hugh Phibbs, will be on view in the Mezzanine Gallery from February 2-23, 2018. A free...

Cost: Free

Where:
Mezzanine Gallery
Carvel State Office Building, 2nd Floor
820 N. French St.
Wilmington, DE  19801
View map »


Sponsor: Delaware Division of the Arts
Telephone: 302-577-8278
Contact Name: Roxanne Stanulis
Website »

More information

A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
View map »


Telephone: 302-654-8638
Website »

More information

This community-curated exhibition brings together three painters—Alan Soffer, Brian Dickerson, and Moe Brooker—who are attuned to harmonies and contrasts in abstract forms. Each artist...

Cost: Free with Museum admission

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »


Website »

More information

By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
View map »

More information

This community event invites attendees to sample healthy dishes prepared by local restaurants and vote for the most creative, tastiest, and best preparation. The first 200 registrants may also sign...

Where:
STAR Health Sciences Complex
540 S. College Ave
Newark, DE  19713
View map »


Website »

More information

Explore connections between people and plants in these four inspiring presentations. Special thanks to Whole Foods Market for sponsoring this  year’s refreshments. Individual lecture pricing:...

Cost: $20 members; $30 non-members

Where:
Delaware Center for Horticulture
1810 N. Dupont Street
Wilmington, DE  19806
View map »


Sponsor: Delaware Center for Horticulture
Telephone: (302) 658-6262
Contact Name: Mackenzie Knight-Fochs
Website »

More information

Tickets are $15 adults; $10 UD faculty/staff/alumni & seniors; $5 students. Tickets are available at the door. Cash or check only.

Cost: $15 adults; $10 UD faculty/staff/alumni & seniors; $5 students

Where:
Gore Recital Hall
110 Orchard Rd
Newark, DE  19716
View map »


Sponsor: University of Delaware Department of Music
Telephone: 130-283-12578
Contact Name: Megan Everhart
Website »

More information

Show More...
Show Less...

"What the water said…Flowers, Places, & Faces," an exhibition of watercolor paintings by Hugh Phibbs, will be on view in the Mezzanine Gallery from February 2-23, 2018. A free...

Cost: Free

Where:
Mezzanine Gallery
Carvel State Office Building, 2nd Floor
820 N. French St.
Wilmington, DE  19801
View map »


Sponsor: Delaware Division of the Arts
Telephone: 302-577-8278
Contact Name: Roxanne Stanulis
Website »

More information

A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
View map »


Telephone: 302-654-8638
Website »

More information

The area’s largest sale of gently used books has been scheduled by the Wilmington branch of the American Association of University Women. The 49th annual Dollars for Scholars Used Book Sale, to...

Cost: free

Where:
Concord Mall
4737 Concord Pike
North Wilmington, DE  19803
View map »


Sponsor: American Association of University Women
Telephone: 302-428-0939

More information

This community-curated exhibition brings together three painters—Alan Soffer, Brian Dickerson, and Moe Brooker—who are attuned to harmonies and contrasts in abstract forms. Each artist...

Cost: Free with Museum admission

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »


Website »

More information

Glory of Stories introduces young visitors to art and the Museum through a story reading followed by an interactive tour of relevant works of art and a studio art project. This program encourages...

Cost: Free to Members, $5 per child and one adult free for Non-Members

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »

More information

By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
View map »

More information

Meeting every Friday, Bayhealth Kent General Hospital, 640 s. State Street, Dover, 7:30 pm., Private Dining Room #3 in the basement. For those who have, or think they may have a gambling problem....

Cost: 0.00

Where:
Bayhealth Kent General Hospital
640 S. State Street
Private Dining Room #3
Dover, DE  19901
View map »


Telephone: 800-855-2CALLGA
Website »

More information

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A winter warm up of colorful, vibrant paintings. Marlene Dubin - bold mixed media abstracts; Elaine Lisle - regional landscapes in oil; Mary Ann Weselyk – whimsical animals and still life...

Cost: free

Where:
The Station Gallery
3922 Kennett Pike
Greenville, DE  19807
View map »


Telephone: 302-654-8638
Website »

More information

The area’s largest sale of gently used books has been scheduled by the Wilmington branch of the American Association of University Women. The 49th annual Dollars for Scholars Used Book Sale, to...

Cost: free

Where:
Concord Mall
4737 Concord Pike
North Wilmington, DE  19803
View map »


Sponsor: American Association of University Women
Telephone: 302-428-0939

More information

This community-curated exhibition brings together three painters—Alan Soffer, Brian Dickerson, and Moe Brooker—who are attuned to harmonies and contrasts in abstract forms. Each artist...

Cost: Free with Museum admission

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »


Website »

More information

Ronald Barron was principal trombonist of the Boston Symphony Orchestra from 1975 until 2008. He joined the orchestra in 1970 after being a member of the Montreal Symphony Orchestra, and also...

Cost: Free

Where:
Gore Recital Hall
110 Orchard Rd
Newark, DE  19716
View map »


Sponsor: University of Delaware Department of Music
Telephone: 130-283-12578
Contact Name: Megan Everhart
Website »

More information

Celebrate the 12th Annual Chinese New Year at the Delaware Art Museum! This celebration includes traditional Chinese art activities, artist demonstrations, a lion and folk dance, a Chinese yo-yo...

Cost: Free; donations accepted

Where:
Delaware Art Museum
2301 Kentmere Parkway
Wilmington, DE  19806
View map »


Website »

More information

By Simon Stephens (playwright of "The Curious Incident of the Dog in the Night-Time") Directed by Matt Pfeiffer REGIONAL PREMIERE! Amidst the bustle of a crowded London train...

Cost: Varies

Where:
Delaware Theatre Company
200 Water Street
Wilmington, DE  19801
View map »

More information

For this Saturday’s activity, visitors will have fun with fluid dynamics and hydraulics - Pascal would be proud! Visitors of all ages are invited to discover solutions to science and engineering...

Cost: Free with admission; Adults: $14, Children 6-14: $5, Children 5 and under: Free

Where:
Hagley Museum and Library
200 Hagley Creek Road
Wilmington, DE  19807
View map »


Telephone: 302-658-2400
Website »

More information

Lights of Life Goes Disco Nights is Delaware’s premier breast cancer fundraiser to benefit the local programs and services of the Delaware Breast Cancer Coalition. Join us for a glamorous, fun...

Cost: *VIP $125.00; *Silver Mirror Ball $50.00

Where:
Dover Downs Hotel
, 1131 North Dupont Highway
Dover, DE  19901
View map »


Sponsor: Delaware Breast Cancer Coalition
Telephone: 302-778-1102
Contact Name: Eliza Mohler
Website »

More information

The Newark Symphony Chamber Orchestra presents a performance of Johann Baptist George Neruda, Trumpet Concerto in E flat, with Wendell Banyay, Trumpet.  Also to be featured will be Gabriel Faure,...

Cost: 0 - $20

Where:
Newark United Methodist Church
69 E. Main St.
Newark, DE  19711
View map »

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